Intraoperative blood transfusions in highly alloimmunized patients undergoing orthotopic liver transplantation.

Intraoperative blood transfusion requirements and deficient hemostasis in highly alloimmunized patients undergoing liver transplantation.

HLA alloimmunization and blood requirements in orthotopic liver transplantation.

ORTHOTOPIC LIVER transplantation (OL T) is often accompanied by massive blood loss due to portal hypertension, difficult dissection as a result of previous abdominal surgery. and coagulation abnormalities. Major alterations of the coagulation factors such as prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT). decreased fibrinogen levels and thrombocytopenia have al...

Comparison of conventional coagulation tests and thromboelastography for preoperatively assessing blood loss and transfusion during orthotopic liver transplantation

Objective: An effective blood loss and transfusion requirements assessment before orthotopic liver transplantation (OLT) may improve intraoperative bleeding management during OLT. Methods: Sixty-five patients were included in this retrospective, observational study. Correlations of conventional coagulation tests (CCTs) and TEG parameters with blood loss and transfusions were determined using Pe...

Intraoperative mannitol does not prevent renal failure in orthotopic liver transplantation.

OBJECTIVE To undertake a prospective randomised controlled study to investigate whether there is any beneficial renal effect in the perioperative administration of mannitol in patients undergoing orthotopic liver transplantation. METHODS Patients presenting in end-stage liver failure for orthotopic liver transplantation had their preoperative renal function assessed by 24 hour urinary creatin...

The Effect of Intraoperative Restricted Normal Saline during Orthotopic Liver Transplantation on Amount of Administered Sodium Bicarbonate

Background: Severe metabolic acidosis occurs during orthotopic liver transplantation (OLT) particularly during the anhepatic phase. Although NaHCO3 is considered as the current standard therapy, there are numerous adverse effects. The aim of this study was to determine whether the restricted use of normal saline during anesthesia could reduce the need for NaHCO3.Methods: In this study we enroll...